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Journal of Tropical Agriculture, Food, Environment and Extension

ISSN 1119-7455
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Article No 12 of Volume 7.1 (2008)
Udem S.C. and Madubunyi  I.I.                 

Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.




The hepatoprotective activity of the root bark extract of Nauclea latifolia was tested in vivo. The root bark was defatted with diethyl ether and then extracted with methanol and the methanolic extract was recovered on a 9.3 % w/w yield. The LD50 of the methanolic extract in rats was 300 mg/kg (i.p). It showed no significant effect on pentobarbital-induced sleep in rats after i.p. injection. The extract significantly reduced pentobarbital-induced sleep in paracetmol and carbon tetrachloride (CCl4) intoxicated rats. The elevataion of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and alkaline phosphatase (AP) induced by paracetamol and CCl4 intoxication in rats was also significantly (P<0.05) attenuated by the extract. The methanolic extract reduced the leakage of lacte dehydrogenase (LDH) in isolated rat heptocytes but had no significant effect on lipid peroxidation. It is suggested that the methanolic extract of N. latifolia might contain hepatoprotective principles that support its use in the treatment of liver diseases traditionally.


Keywords: Nauclea latifolia, Folk medicine, hepatoprotective, Tashi ya igiya, Ubiri agu

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